Reactome-Recon List 1

These tables contain proteins from the Human Metabolic Reconstruction Recon2 that match those in Reactome pathways and participate in signalling processes, the cases when a protein connected to a process via production or consumption arcs. Table 1 includes phosphorylation processes, while Table 2 includes other types of processes.

Table 1 : Signalling phosphorylation processes & Recon2 catalyzers

UniProt ID HGNC Symbol Reactome Process Available Maps
Q9NYG5 ANAPC11 Phosphorylation of Cdh1 by Cyclin A:Cdk2  
P32119 PRDX2 CDK5:p25 phosphorylates PRDX2  
P06737 PYGL glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP  
P09917 ALOX5 ALOX5 is phosphorylated by MAPKAP2  
P29474 NOS3 AKT1 phosphorylates eNOS  
P11217 PYGM glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP Glycogen metabolism
P19174 PLCG1 Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants  
Q06830 PRDX1 CDK5:p25 phosphorylates PRDX1  
P11216 PYGB glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP  
P15328 FOLR1 CSNK1D phosphorylates SEC23  
Q03393 PTS PTPS is phosphorylated by cGMP-dependant protein kinase II  
P16885 PLCG2 Phosphorylation and activation of PLCG  
P14672 SLC2A4 GLUT4 vesicle fuses with the plasma membrane  
P35270 SPR Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II  
Q9NY65 TUBA8 Phosphorylation of cohesin by PLK1 at centromeres  
P00533 EGFR Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants Inositol phosphate
Q16555 DPYSL2 Phosphorylation of CRMPs by Cdk5  
P09622 DLD BCKDK phosphorylates BCKDH  
P47712 PLA2G4A Phosphorylation of cPLA2 by ERK-2 Eicosanoid production


Table 2a : Other signalling processes & Recon2 catalyzers

UniProt ID HGNC Symbol Reactome Process Available Maps
P11926 ODC1 Antizyme OAZ binds to Ornithine decarboxylase  
Q5FWF5 ESCO1 Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2  
P08559 PDHA1 PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit  
P06737 PYGL poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]  
P06858 LPL chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols  
P19174 PLCG1 PLCG1 binds to ligand-responsive p-6Y-EGFR mutants  
Q5VV43 KIAA0319 F- and N- BAR domain proteins bind the clathrin-coated pit  
P15328 FOLR1 Vesicle budding  
P25092 GUCY2C GUCY2C trimer binds GUCA2A,B Estradiol biosynthesis
Q9Y4K0 LOXL2 Elastin cross-linking by lysyl oxidase  
Q9Y6K1 DNMT3A PRC2 recruits DNA methyltransferases  
P30048 PRDX3 PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O  
Q05329 GAD2 Release of GABA at the synapse  
Q96RQ3 MCCC1 HLCS biotinylates MCCC1:MCCC2  
P16066 NPR1 NPPA(124-151) binds NPR1  
P20594 NPR2 NPR2 binds NPPC  
P15291 B4GALT1 Association of ADAM and B4GALT1 With ZP3  
Q16795 NDUFA9 Intermediate 1 binds HP subcomplex to form Intermediate 2  
Q16555 DPYSL2 Interaction of NUMB with L1  
P47712 PLA2G4A Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase Eicosanoid production
P06865 HEXA Hexosaminidase A cleaves GalNAc from GM2 to form GM3  
P32019 INPP5B GAPs inactivate Rho GTPase:GTP by hydrolysis Inositol phosphate
Q8TC12 RDH11 RDH10,11 oxidise 11cROL to 11cRAL  
P11217 PYGM poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] Glycogen metabolism
O75610 LEFTY1 LEFTY binds NODAL  
Q9UBC3 DNMT3B PRC2 recruits DNA methyltransferases  
O75452 RDH16 RDH5 oxidises 11cROL to 11cRAL  
P11216 PYGB PGYB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP  
Q9NQR1 KMT5A SETD8 monomethylates histone H4  
P17516 AKR1C4 AKRs reduce RBP2:atRAL to RBP2:atROL  
P11498 PC HLCS biotinylates PC:Mn2+  
O75251 NDUFS7 NUBPL transfers 4Fe-4S to Complex I subunits  
Q9BYF1 ACE2 ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)  
Q08828 ADCY1 G alpha (s) activates adenylate cyclase  
O60331 PIP5K1C Inhibition of integrin activation by sequestering PIP5KIgamma  
Q9NY59 SMPD3 TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3  
P08574 CYC1 Electron transfer from ubiquinol to cytochrome c of complex III  
P47985 UQCRFS1 Electron transfer from ubiquinol to cytochrome c of complex III  
P00533 EGFR F- and N- BAR domain proteins bind the clathrin-coated pit Inositol phosphate
P07686 HEXB Hexosaminidase A cleaves GalNAc from GM2 to form GM3  
P47989 XDH BTN1A1 binds xanthine oxidoreductase (XDH)  
P09622 DLD PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit  
Q92835 INPP5D Interaction of PECAM-1 and SHIP  
P29474 NOS3 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle  
P31350 RRM2 RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)  
P35354 PTGS2 PTGS2 dimer binds celecoxib  
O00443 PIK3C2A trans-Golgi Network Coat Assembly  
O95299 NDUFA10 Intermediate 1 binds HP subcomplex to form Intermediate 2  
P19634 SLC9A1 HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+  
Q9NY65 TUBA8 ERGIC-to-Golgi vesicles bind dynein:dynactin  
P04180 LCAT LCAT + discoidal HDL <=> LCAT:discoidal HDL complex  
Q96KQ7 EHMT2 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2  
O60266 ADCY3 G alpha (s) activates adenylate cyclase  
P31040 SDHA Transfer of electrons through the succinate dehydrogenase complex  
P00441 SOD1 CCS transfers Cu to SOD1  
P26358 DNMT1 PRC2 recruits DNA methyltransferases  
O43463 SUV39H1 eNoSC deacetylates histone H3  
O95622 ADCY5 G alpha (s) activates adenylate cyclase  
Q9NYG5 ANAPC11 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2  
P32119 PRDX2 PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O  
P51970 NDUFA8 Intermediate 1 binds HP subcomplex to form Intermediate 2  
P78356 PIP4K2B PIN1 binds phosphorylated PIP4K2B  
O43306 ADCY6 G alpha (s) activates adenylate cyclase  
Q06830 PRDX1 PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O  
O43865 AHCYL1 AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it  
P16885 PLCG2 Recruitment of PLCgamma to membrane  
P15289 ARSA Active ARSA translocates to the lysosome  
P08195 SLC3A2 Basigin binds CD98 complex  
P25874 UCP1 FA anion flip-flops to the opposite surface  


Table 2b : Expression signalling processes & Recon2 catalyzers

UniProt ID HGNC Symbol Reactome Process Available Maps
O95477 ABCA1 Expression of ABCA1  
Q16790 CA9 Expression of Carbonic Anhydrase IX (CA9)  
Q9H5J4 ELOVL6 Expression of ELOVL6  
P54868 HMGCS2 Expression of HMGCS2 Mevalonate biosynthesis
P04179 SOD2 SOD2 (MnSOD) gene expression  
Q16881 TXNRD1 Expression of TXNRD1  
Q06520 SULT2A1 Expression of SULT2A1  
O00763 ACACB Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) Acyl-carnitine synthesis
P35558 PCK1 Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)  
P11310 ACADM Expression of ACADM  
P14672 SLC2A4 Expression of GLUT4  
P21439 ABCB4 Expression of ABCB4  
O14773 TPP1 Expression of TPP1  
P0DMM9 SULT1A3 Expression of SULT1A3  
P49748 ACADVL Expression of ACADVL