Regulation of pyrimidine biosynthesis via MAPK signalling

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Contributors

Hanna Borlinghaus, Falk Schreiber, John Albanese (annotation)

Description

The activation of de novo pyrimidine biosynthesis is a requirement for cell proliferation in tumor tissues. The carbamoyl phosphate synthetase (CPSase) catalyses the rate-limiting step of the synthetic pathway. CPSase refers to one catalytic activity of the multifunctional protein CAD that catalyses the first three steps of the pathway.

References

  1. Sigoillot FD, Sigoillot SM, Guy HI. Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells. Int J Cancer. 2004 Apr 20;109(4):491-8. PMID: 14991569.

  2. Sigoillot FD, Evans DR, Guy HI. Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades. J Biol Chem. 2002 May 3;277(18):15745-51. Epub 2002 Feb 28. PMID: 11872754.