Regulation of mevalonate synthesis

Downloads:   GraphML   SBGN-ML   Newt   Anotated Map  

Contributors

James Greene, Michael Blinov, Alexander Mazein

References

  1. Miziorko, H. M. (2011). Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Archives of biochemistry and biophysics, 505(2), 131-143.
  2. Goldstein, J. L., and Brown, S. B. (1990) Regulation of the mevalonate pathway. Nature 343, 425−430
  3. Reactome Pathways https://reactome.org/content/detail/R-HSA-191273
  4. Clarke, P. R., & Hardie, D. G. (1990). Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver. The EMBO journal, 9(8), 2439-2446.
  5. Sharpe, L. J., & Brown, A. J. (2013). Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). Journal of Biological Chemistry, 288(26), 18707-18715.
  6. Joseph, B. K., Liu, H. Y., Francisco, J., Pandya, D., Donigan, M., Gallo-Ebert, C., … & Nickels, J. T. (2015). Inhibition of AMP kinase by the protein phosphatase 2A heterotrimer, PP2APpp2r2d. Journal of Biological Chemistry, 290(17), 10588-10598.
  7. Pang Ching, Y., Kobayashi, T., Tamura, S., & Grahame Hardie, D. (1997). Specificity of different isoforms of protein phosphatase‐2A and protein phosphatase‐2C studied using site‐directed mutagenesis of HMG‐CoA reductase. FEBS letters, 411(2-3), 265-268.
  8. Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., … & Hardie, D. G. (2005). Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell metabolism, 2(1), 9-19.
  9. Reactome Pathways https://reactome.org/content/detail/R-HSA-380930
  10. Figshare: Pappa et al., 2012, Regulation of HMGCR in the mevalonte pathway, https://doi.org/10.6084/m9.figshare.105160.v2