Selected topics

This list includes the developed diagrams and suggested topics. Some initial information for suggested topics is provided in this online document accessible for collaborative editing.

  1. Regulation of glycolysis via PFKFB (Alexander Mazein, Vasundra Touré)
  2. Regulation of mevalonate biosynthesis (James Greene, Michael Blinov, Alexander Mazein)
  3. Regulation of eicosanoid production (Alexander Mazein)
  4. Regulation of glycogen metabolism (Tatiana Serebriyskaya, Valeriya Berzhitskaya, Vasundra Touré)
  5. Regulation of cholesterol metabolism via SREBP (Tatiana Serebriyskaya, Valeriya Berzhitskaya)
  6. Regulation of acetyl-CoA synthesis (Adrien Rougny)
  7. Regulation of nitric oxide production - iNOS pathway (Alexander Mazein)
  8. Regulation of nitric oxide production - eNOS pathway (Olga Ivanova)
  9. Regulation of phosphoinositide metabolism (James Greene, Michael Blinov)
  10. Regulation of cAMP hydrolysis (Tatiana Serebriyskaya, Valeriya Berzhitskaya)
  11. Regulation of acyl-carnitine synthesis (Tatiana Serebriyskaya, Valeriya Berzhitskaya)
  12. Regulation of triacylglycerol hydrolysis (Tatiana Serebriyskaya, Valeriya Berzhitskaya)
  13. Regulation of estradiol biosynthesis via prostaglandin-mediated… (Hanna Borlinghaus, Falk Schreiber)
  14. Regulation of pyrimidine biosynthesis via MAPK signalling (Hanna Borlinghaus, Falk Schreiber)
  15. Regulation of glutaminolysis via the NF-kB-PKCe axis in lung cancer cells (Hanna Borlinghaus, Falk Schreiber)
  16. Regulation of eisocanoid metabolism by aspirin (Alexander Mazein)
  17. PKA activation (versions, important for many metabolism regulation pathways)
  18. AMPK activation (versions, important for many metabolism regulation pathways)

Reactome-Recon lists

Reactome-Recon lists were generated automatically using a combination of two resources: the Reactome Neo4j graph database (Fabregat et al., 2018) and the Recon Neo4j graph database (Balaur et al., 2016) of the Human Metabolic Network Reconstruction Recon2 (Thiele et al., 2011).

Reactome-Recon List 1 - Proteins

The list includes proteins from Recon2 that match those in Reactome pathways and participate in signalling processes in Reactome pathways as a reactant or a product, the cases when a protein is connected to a process via a production or a consumption arc.

Reactome-Recon List 2 - Complexes

This list includes proteins from Recon2 that are also involved in the complexes that participate in signalling processes in Reactome pathways as reactants or products.