Regulation of glutaminolysis via the NF-kB-PKCe axis in lung cancer cells

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Contributors

Hanna Borlinghaus, Falk Schreiber, Maria Heredia Chavez (annotation)

Description

Glutaminase C (GAC) catalyses the conversion of glutamine to glutamate. Glutamate then enters the tricarboxylic cycle. High availability of glutamate is important for tumor cells to satisfy their increased need for energy and synthesis of macromolecules.

References

  1. Ryu JM, Lee SH, Seong JK, Han HJ. Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a. Cell Cycle. 2015;14(20):3292-305. doi: 10.1080/15384101.2015.1087620. PMID: 26375799.