Regulation of acyl-carnitine synthesis

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Contributors

Tatiana Serebriyskaya, Valeriya Berzhitskaya, Maria Heredia Chavez (annotation)

Description

The carnitine palmitoyltransferase system is responsible for delivering the long-chain fatty acid from cytoplasm into mitochondria for oxidation, where carnitine palmitoyltransferase 1 (CPT1) catalyzes the rate-limiting step of fatty acid oxidation that plays an important role in lipid metabolism.

References

  1. KEGG Pathway Maps: Glucagon signaling pathway
  2. Database dbPTM: STK11_HUMAN
  3. Database dbPTM: ACACB_HUMAN
  4. Qu Q, Zeng F, Liu X, Wang QJ, Deng F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell Death Dis. 2016 May 19;7:e2226. PMID: 27195673
  5. Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med. 2004 Oct-Dec;25(5-6):495-520. PMID: 15363638
  6. Flavin R, Peluso S, Nguyen PL, Loda M. Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol. 2010 Apr;6(4):551-62. PMID: 20373869
  7. Schreurs M, Kuipers F, van der Leij FR. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev. 2010 May;11(5):380-8. PMID: 19694967
  8. Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev. 2009 Jul;89(3):777-98. PMID: 19584313
  9. Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene. 2008 Nov 24;27(55):6908-19. PMID: 19029933